Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077860" target="_blank" >RIV/00023001:_____/19:00077860 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/19:00517436 RIV/68378041:_____/19:00517436 RIV/60461373:22340/19:43917736 RIV/00216208:11110/19:10397522
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/open.201800261" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1002/open.201800261</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/open.201800261" target="_blank" >10.1002/open.201800261</a>

Result language
angličtina
Original language name
Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo
Original language description
Manganese-zinc ferrite nanoparticles were synthesized by using a hydrothermal treatment, coated with silica, and then tested as efficient cellular labels for cell tracking, using magnetic resonance imaging (MRI) in vivo. A toxicity study was performed on rat mesenchymal stem cells and C6 glioblastoma cells. Adverse effects on viability and cell proliferation were observed at the highest concentration (0.55 mM) only; cell viability was not compromised at lower concentrations. Nanoparticle internalization was confirmed by transmission electron microscopy. The particles were found in membranous vesicles inside the cytoplasm. Although the metal content (0.42 pg Fe/cell) was lower compared to commercially available iron oxide nanoparticles, labeled cells reached a comparable relaxation rate R-2, owing to higher nanoparticle relaxivity. Cells from transgenic luciferase-positive rats were used for in vivo experiments. Labeled cells were transplanted into the muscles of non bioluminescent rats and visualized by MRI. The cells produced a distinct hypointense signal in T-2 - or T-2*-weighted MR images in vivo. Cell viability in vivo was verified by bioluminescence.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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