Colorectal adenomas - genetics and searching for new molecular screening biomarkers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079672" target="_blank" >RIV/00023001:_____/20:00079672 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1422-0067/21/9/3260/htm" target="_blank" >https://www.mdpi.com/1422-0067/21/9/3260/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms21093260" target="_blank" >10.3390/ijms21093260</a>

Result language

angličtina

Original language name

Colorectal adenomas - genetics and searching for new molecular screening biomarkers

Original language description

Colorectal cancer (CRC) is a malignant disease with an incidence of over 1.8 million new cases per year worldwide. CRC outcome is closely related to the respective stage of CRC and is more favorable at less advanced stages. Detection of early colorectal adenomas is the key to survival. In spite of implemented screening programs showing efficiency in the detection of early precancerous lesions and CRC in asymptomatic patients, a significant number of patients are still diagnosed in advanced stages. Research on CRC accomplished during the last decade has improved our understanding of the etiology and development of colorectal adenomas and revealed weaknesses in the general approach to their detection and elimination. Recent studies seek to find a reliable non-invasive biomarker detectable even in the blood. New candidate biomarkers could be selected on the basis of so-called liquid biopsy, such as long non-coding RNA, microRNA, circulating cell-free DNA, circulating tumor cells, and inflammatory factors released from the adenoma into circulation. In this work, we focused on both genetic and epigenetic changes associated with the development of colorectal adenomas into colorectal carcinoma and we also discuss new possible biomarkers that are detectable even in adenomas prior to cancer development. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30101 - Human genetics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of molecular sciences

ISSN

1661-6596

e-ISSN

—

Volume of the periodical

21

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

23

Pages from-to

"art. no. 3260"

UT code for WoS article

000535581700231

EID of the result in the Scopus database

2-s2.0-85084381826