Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00081063" target="_blank" >RIV/00023001:_____/20:00081063 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/20:43921667
Result on the web
<a href="https://fb.cuni.cz/file/5936/fb2020a0022.pdf" target="_blank" >https://fb.cuni.cz/file/5936/fb2020a0022.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn
Original language description
Rapid wound closure in extensively burned patients has remained one of the major unresolved issues of medicine. Integra (R) is the most widely established artificial skin, which is composed of a porous matrix of cross-linked bovine collagen and chondroitin 6-sulphate covered by a semi-permeable silicone layer. We present here a (immuno)histological study of a severely burned patient with a full-thickness burn treated with a tissue-engineered dermal template (Integra (R)) and split-thickness skin graft-based protocol. Immunohistochemical investigation of the artificial dermis revealed that immune cell infiltration reached its peak on day 10. Tissue immunophenotyping found an increase in CD3(+) cells over the course of the study as well as CD4 and CD8 positivity on day 40, indicating remaining T-cell subpopulations. We observed weak/no infiltration of NK cells (CD56(+)). In conclusion, the use of bi-layer Integra (R) represents a feasible and safe procedure resulting in formation of non-irritating dermal substitutes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30216 - Dermatology and venereal diseases
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia biologica (Praha)
ISSN
0015-5500
e-ISSN
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Volume of the periodical
66
Issue of the periodical within the volume
5-6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
161-168
UT code for WoS article
000669523700002
EID of the result in the Scopus database
2-s2.0-85107792444