Magnetic resonance markers of bilateral neuronal metabolic dysfunction in patients with unilateral internal carotid artery occlusion

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080791" target="_blank" >RIV/00023001:_____/21:00080791 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/20:00000706 RIV/44555601:13450/20:43895917 RIV/00216208:11110/21:10412527 RIV/00216208:11130/21:10412527 and 2 more

Result on the web

<a href="https://link.springer.com/content/pdf/10.1007/s10334-020-00864-2.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s10334-020-00864-2.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10334-020-00864-2" target="_blank" >10.1007/s10334-020-00864-2</a>

Result language

angličtina

Original language name

Magnetic resonance markers of bilateral neuronal metabolic dysfunction in patients with unilateral internal carotid artery occlusion

Original language description

Objectives To evaluate cerebral hemodynamic, metabolic and anatomic changes occurring in patients with unilateral occlusion of the internal carotid artery (ICA). Materials and methods Twenty-two patients with unilateral occlusion of ICA and twenty age and sex matched healthy subjects were included in the study. Single voxel proton magnetic resonance spectroscopy (H-1-MRS) of the centrum semiovale, semi-automated hippocampal volumetry in T1-weighted scans and transcranial Doppler examination (TCD) with calculation of Breath Holding Index (BHI) were performed in both groups. Metabolic, anatomic, and hemodynamic features were compared between the two groups. Results TheN-acetylaspartate (NAA)/choline (Cho) ratio was significantly lower in both hemispheres of enrolled patients compared to controls (p = 0.005 for the side with occlusion,p = 0.04 for the side without occlusion). The hippocampus volume was significantly reduced bilaterally in patients compared to healthy subjects (p = 0.049). A statistically significant difference in BHI values was observed between the side with occlusion and without occlusion (p = 0.037) of the patients, as well as between BHI values of the side with occlusion and healthy volunteers (p = 0.014). Discussion Patients with unilateral ICA occlusion have reduced NAA/Cho ratio in the white matter of both hemispheres and have bilateral atrophy of hippocampus. The alteration of hemodynamics alone cannot explain these changes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Magnetic resonance materials in physics, biology and medicine

ISSN

0968-5243

e-ISSN

—

Volume of the periodical

34

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

141-151

UT code for WoS article

000543707600001

EID of the result in the Scopus database

2-s2.0-85087312072