The Role of Connexin 37 Polymorphism in Spontaneous Abortion
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081475" target="_blank" >RIV/00023001:_____/21:00081475 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10427642 RIV/00064203:_____/21:10427642 RIV/00216208:11130/21:10427642
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2021/70_469.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2021/70_469.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934566" target="_blank" >10.33549/physiolres.934566</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Connexin 37 Polymorphism in Spontaneous Abortion
Original language description
Among unique cardiovascular risk factors in women are complications during pregnancy, including miscarriage. Important risk factor is also genetic background. One of powerful candidate genes for cardiovascular disease of atherosclerotic origin (aCVD) is gene for connexin 37 (Cx37) with strong gene-environment interaction including smoking status, that is also strong risk factor for complications in pregnancy including spontaneous abortion (SA). We analyzed association between SA and Cx37 gene polymorphism (1019C>T; Pro319Ser) in 547 fetuses and its potential interaction with smoking status of mothers. Using genetic analyses from women from general population as controls, ORs for T allele, found in our previous studies to be protective against aCVD, were calculated. T allele carriers (fetuses), had OR 0.91 (95 % CI 0.72-1.14) and no interaction with smoking was observed. In conclusion, no significant association between Cx37 polymorphism and SA was observed and no modifying effect of smoking status on this association was detected.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
70
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
469-474
UT code for WoS article
000675528500014
EID of the result in the Scopus database
2-s2.0-85112124640