Statins and Inflammation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081787" target="_blank" >RIV/00023001:_____/21:00081787 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10434704 RIV/00064165:_____/21:10434704
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s11883-021-00977-6.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s11883-021-00977-6.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11883-021-00977-6" target="_blank" >10.1007/s11883-021-00977-6</a>
Alternative languages
Result language
angličtina
Original language name
Statins and Inflammation
Original language description
Purpose of Review Chronic inflammation has been recognized as one of the most important pathophysiological mechanisms' initiation and progression of atherosclerosis. Statins belong to most successful therapeutic agents in the prevention and treatment of atherothrombotic vascular disease. Their non-lipid related effects including suppression of inflammation have been repeatedly proven in both experimental and clinical settings. Recent Findings Recently, the importance of inflammation in the process of atherosclerosis has been confirmed by interventions targeting inflammation selectively. Clinical trial with selective inhibitor of a principal inflammatory mediator interleukin 1-beta - canakinumab - confirmed the notion of direct vasculoprotective effects of primarily targeting inflammation. This has increased interest in the non-lipid, pleiotropic and, particularly, anti-inflammatory effects of statins. Summary Anti-inflammatory effects of statins have been proven both experimentally and in clinical settings beyond any doubt. They comprise a direct positive effect on not only many cell types and pathways that are lipid independent but, also, some that are mediated by lipid modification. Undoubtedly, suppression of inflammatory response by statins contributes to their generally positive action in atherosclerosis and represents an important part of the vasculo- and atheroprotective effect of this drug class.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NU21-01-00146" target="_blank" >NU21-01-00146: Analysis of free DNA and miRNA as markers of muscle damage in statin-treated patients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current atherosclerosis reports
ISSN
1523-3804
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
12
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
"art. no. 80"
UT code for WoS article
000724753700001
EID of the result in the Scopus database
2-s2.0-85120355548