APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084981" target="_blank" >RIV/00023001:_____/24:00084981 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10484186
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/mgg3.2449" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/mgg3.2449</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mgg3.2449" target="_blank" >10.1002/mgg3.2449</a>
Alternative languages
Result language
angličtina
Original language name
APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males
Original language description
BACKGROUND: The highest mortality and morbidity worldwide is associated with atherosclerotic cardiovascular disease (ASCVD), which has in background both environmental and genetic risk factors. Apolipoprotein L1 (APOL1) variability influences the risk of ASCVD in Africans, but little is known about the APOL1 and ASCVD in other ethnic groups. METHODS: To investigate the role of APOL1 and ASCVD, we have genotyped four (rs13056427, rs136147, rs10854688 and rs9610473) APOL1 polymorphisms in a group of 1541 male patients with acute coronary syndrome (ACS) and 1338 male controls. RESULTS: Individual APOL1 polymorphisms were not associated with traditional CVD risk factors such as smoking, hypertension or diabetes prevalence, with BMI values or plasma lipid levels. Neither individual polymorphisms nor haplotypes were associated with an increased risk of ACS nor did they predict total or cardiovascular mortality over the 10.2 ± 3.9 years of follow-up. CONCLUSIONS: We conclude that APOL1 genetic variability has no major effect on risk of ACS in Caucasians.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular genetics & genomic medicine
ISSN
2324-9269
e-ISSN
2324-9269
Volume of the periodical
12
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"art. no. e2449"
UT code for WoS article
001296010600001
EID of the result in the Scopus database
2-s2.0-85201816804