Impact of angiotensin receptor blockers (ARB) versus other antihypertensive medication on blood pressure in patients on dialysis: a meta-analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085141" target="_blank" >RIV/00023001:_____/24:00085141 - isvavai.cz</a>
Result on the web
<a href="https://indianjnephrol.org/impact-of-angiotensin-receptor-blockers-arb-versus-other-antihypertensive-medication-on-blood-pressure-in-patients-on-dialysis-a-meta-analysis/" target="_blank" >https://indianjnephrol.org/impact-of-angiotensin-receptor-blockers-arb-versus-other-antihypertensive-medication-on-blood-pressure-in-patients-on-dialysis-a-meta-analysis/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.25259/ijn_365_23" target="_blank" >10.25259/ijn_365_23</a>
Alternative languages
Result language
angličtina
Original language name
Impact of angiotensin receptor blockers (ARB) versus other antihypertensive medication on blood pressure in patients on dialysis: a meta-analysis
Original language description
Introduction: Hypertension is an important factor driving mortality among dialysis patients. Angiotensin-II receptor blocker (ARB) has been effective similarly to angiotensin-converting enzymes (ACEs) but with a low incidence of side effects. Methodology: The meta-analysis included all published studies that investigated the effect of ARB on the hypertension in adult dialysis patients (≥18 years). Data extraction was guided by a predetermined checklist. Data sources of the retrieved studies were PubMed, MEDLINE, ScienceDirect, SCOPUS, Cochrane, Web of knowledge, and Google Scholar were systematically searched until February 2023. Using the RevMan 5 software, the mean difference for systolic and diastolic BP (SBP and DBP) and the risk ratio (RR) of the adverse events (AEs) were pooled from the selected studies. The random-effects model was used to compare the difference in the pre-and post-dialysis of the SBP and DBP. Data analyses were performed from December 2022 to February 2023. The primary outcome was the reduction in SBP and DBP in dialysis hypertensive patients who were on anti-hypertensive agents, and the secondary outcome was assessment of AE associated with the drug after dialysis (PROSPERO Registration: CRD42022355369). Results: The initial search yielded 1,679 records, of which 84 studies underwent full-text evaluation, which identified 13 studies and 1,462 patients. The pooled standard MD for losartan with other antihypertensive agents, where the pre-dialysis SBP was 0.17 (95% confidence interval [CI]: −0.21–0.55) and the post-dialysis was 0.35 (95% CI: −0.17–1.02); yet, both are statistically non-significant, implies that there was no difference between Losartan and ARB drugs regarding the effect on the SBP. Diastolic BP for predialysis was −0.01 (95% CI: −0.65–0.63) and post-dialysis was 0.03 (95% CI: −0.24−0.30) and statistically non-significant. AEs by the ARB agents were lower compared to other anti-antihypertensive agents (relative risk [RR]: 1.01; 95% CI: 0.59–1.75) and statistically non-significant. Conclusion: This systematic review and meta-analysis of RCT demonstrated that ARB and other anti-hypertensive medications had similar impacts on the treatment of hypertension. © 2024 Indian Journal of Nephrology.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Indian Journal of Nephrology
ISSN
0971-4065
e-ISSN
1998-3662
Volume of the periodical
34
Issue of the periodical within the volume
5
Country of publishing house
IN - INDIA
Number of pages
11
Pages from-to
431-441
UT code for WoS article
001356594300003
EID of the result in the Scopus database
2-s2.0-85203137003