Semaglutide treatment effects on liver fat content in obese subjects with Metabolic-Associated Steatotic Liver Disease (MASLD)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085178" target="_blank" >RIV/00023001:_____/24:00085178 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/24:10497205

Result on the web

<a href="https://www.mdpi.com/2077-0383/13/20/6100" target="_blank" >https://www.mdpi.com/2077-0383/13/20/6100</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm13206100" target="_blank" >10.3390/jcm13206100</a>

Result language

angličtina

Original language name

Semaglutide treatment effects on liver fat content in obese subjects with Metabolic-Associated Steatotic Liver Disease (MASLD)

Original language description

Background: Metabolic-dysfunction-associated steatotic liver disease (MASLD) represents a major clinical complication of obesity. Methods: In this study, we used magnetic resonance (MR) methods to determine the effect of obesity treatment with semaglutide, a GLP-1 receptor agonist, on the liver fat content and selected metabolic variables. We investigated whether treatment would affect the acute response of liver fat to glucose and fructose administration and whether it would affect the fatty acid profile of VLDL-triglycerides. Sixteen obese non-diabetic men underwent a 16-week dietary intervention and 16-week treatment with subcutaneous semaglutide in a crossover design without a washout period. The order of the interventions was randomized. Results: After treatment, body weight of the subjects decreased by 5% and liver fat by a third, whereas dietary intervention had no impact on these parameters. The decrease in liver fat with semaglutide did not correlate with changes in body weight and other measures of adiposity and was unrelated to improved insulin sensitivity. Conclusions: The proportion of palmitic and palmitoleic acids in VLDL-triglycerides decreased after treatment, suggesting that the beneficial effects of semaglutide on liver fat are mediated by the suppression of de novo lipogenesis.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

<a href="/en/project/NU20-01-00121" target="_blank" >NU20-01-00121: The effect of semaglutide administration on the the acute response of liver fat content to the administration of simple carbohydrates</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of clinical medicine

ISSN

2077-0383

e-ISSN

2077-0383

Volume of the periodical

13

Issue of the periodical within the volume

20

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

"art. no. 6100"

UT code for WoS article

001341403100001

EID of the result in the Scopus database

2-s2.0-85207670737