CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085389" target="_blank" >RIV/00023001:_____/25:00085389 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/25:00379367

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/jce.16525" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/jce.16525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jce.16525" target="_blank" >10.1111/jce.16525</a>

Result language

angličtina

Original language name

CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients

Original language description

IntroductionA variable proportion of non-responders to cardiac resynchronization therapy (CRT) warrants the search for new approaches to optimize the position of the left ventricular (LV) lead and the CRT device programming. CineECG is a novel ECG modality proposed for the spatial visualization and quantification of myocardial depolarization and repolarization sequences. ObjectiveThe present study aimed to evaluate CineECG-derived parameters in different pacing modes and to test their associations with acute hemodynamic responses in CRT patients. Methods and ResultsCineECG was used to construct the average electrical path within the cardiac anatomy from the 12-lead ECG. CineECG and LV dP/dt max were tested in 15 patients with nonischemic dilated cardiomyopathy and left bundle branch block (QRS: 170 +/- 17 ms; LVEF: 26 +/- 5.5%) under pacing protocols with different LV lead localizations. The CineECG-derived path directions were computed for the QRS and ST-T intervals for the anteroposterior (Xh), interventricular (Yh), and apicobasal (Zh) axes. In a multivariate linear regression analysis with adjustment for the pacing protocol type, the ST-T path direction Yh was independently associated with the increase in dP/dt max during CRT, [regression coefficient 639.4 (95% confidence interval: 187.9-1090.9), p = 0.006]. In ROC curve analysis, the ST-T path direction Yh was associated with the achievement of a 10% increase in dP/dt max (AUC: 0.779, p = 0.002) with the optimal cut-off &gt; 0.084 (left-to-right direction) with sensitivity 0.67 and specificity 0.92. ConclusionThe acute hemodynamic response in CRT patients was associated with specific CineECG repolarization sequence parameters, warranting their further testing as potential predictors of clinical outcomes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of cardiovascular electrophysiology

ISSN

1045-3873

e-ISSN

1540-8167

Volume of the periodical

36

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

338-346

UT code for WoS article

001368620500001

EID of the result in the Scopus database

2-s2.0-85210747965