Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F25%3AN0000014" target="_blank" >RIV/00023698:_____/25:N0000014 - isvavai.cz</a>
Alternative codes found
RIV/27661989:_____/25:10003004 RIV/61988987:17110/25:A2603DQC RIV/00216208:11120/25:43928003 RIV/70883521:28150/25:63594521
Result on the web
<a href="https://fn.bmj.com/content/110/6/542" target="_blank" >https://fn.bmj.com/content/110/6/542</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/archdischild-2024-327894" target="_blank" >10.1136/archdischild-2024-327894</a>
Alternative languages
Result language
angličtina
Original language name
Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age
Original language description
Objective To determine survival and neurodevelopmental outcomes in the Hypotension in Preterm (HIP) trial.Design Prospective follow-up of infants enrolled in randomised controlled trial.Participants 58 infants born before 28 weeks of gestation with low mean arterial blood pressure.Intervention Random allocation to treatment of low blood pressure values with infusion of dopamine or placebo.Primary outcome Survival without neurodevelopmental impairment to 24 months corrected age (CA).Results The HIP trial stopped early due to logistic and recruitment difficulties. Outcomes were determined for 55 infants (27 in the dopamine group and 28 in the placebo group) at 24 months CA. Survival without impairment was present in 13 (48%) infants in the dopamine group and 7 (25%) infants in the placebo group (OR 2.79 (95% CI 0.89, 8.72); p=0.078). The components of the primary outcome were similarly distributed between the two arms. Mean Bayley composite scores and the frequency of somatic impairments did not differ significantly between groups but infants were shorter and lighter at 2 years of age after dopamine administration.Conclusion In this placebo-controlled trial of the treatment of hypotension in extremely preterm infants, dopamine administration did not increase survival without impairment at 2 years CA. However, the study was not sufficiently powered and a clinically important effect cannot be excluded. The role of inotropic medication in facilitating good outcomes requires further study.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
ISSN
1359-2998
e-ISSN
1468-2052
Volume of the periodical
110
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
542-547
UT code for WoS article
001407136600001
EID of the result in the Scopus database
2-s2.0-85216115865