Polymyositis: does it really exist as a distinct clinical subset?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F21%3AN0000059" target="_blank" >RIV/00023728:_____/21:N0000059 - isvavai.cz</a>
Result on the web
<a href="https://journals.lww.com/co-rheumatology/Abstract/2021/11000/Polymyositis__does_it_really_exist_as_a_distinct.12.aspx" target="_blank" >https://journals.lww.com/co-rheumatology/Abstract/2021/11000/Polymyositis__does_it_really_exist_as_a_distinct.12.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/BOR.0000000000000837" target="_blank" >10.1097/BOR.0000000000000837</a>

Result language
angličtina
Original language name
Polymyositis: does it really exist as a distinct clinical subset?
Original language description
Purpose of review To summarize information on polymyositis; diagnosis, definitions, published data and opinions. Recent findings Polymyositis originally referred to inflammatory muscle diseases presenting with muscle weakness and inflammatory cell infiltrates on muscle tissue visible by microscopy. Over time and with improved technology to immunophenotype infiltrating inflammatory cells and characterize muscle fibres, the meaning of polymyositis changed and became more specific. There is ongoing controversy over the term polymyositis, with proponents for a strict definition based on histopathological and immunohistochemical features on muscle biopsies whereas others advocate for a broader clinical and histopathological phenotype. Over the past decades, the discovery of several myositis-specific autoantibodies together with distinct histopathological features have enabled the identification of new subsets previously labelled as polymyositis notably the antisynthetase syndrome and the immune-mediated necrotizing myopathies thus reducing the number of patients classified as polymyositis. There are still a small number of patients among the idiopathic inflammatory myopathies that can be classified as polymyositis as discussed in this review but the entity is now considered relatively rare.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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