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Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F23%3AN0000009" target="_blank" >RIV/00023728:_____/23:N0000009 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/23:10472364 RIV/00216208:11320/23:10472364 RIV/00098892:_____/23:10158303 RIV/00064165:_____/23:10472364

  • Result on the web

    <a href="https://doi.org/10.1186/s13075-023-03204-6" target="_blank" >https://doi.org/10.1186/s13075-023-03204-6</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s13075-023-03204-6" target="_blank" >10.1186/s13075-023-03204-6</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment

  • Original language description

    Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be affected by urate-lowering treatment (ULT). Our study aimed to evaluate differences in plasma lipidome between patients with asymptomatic HUA detected ≤ 40 years (HUA ≤ 40) and > 40 years, gout patients with disease onset ≤ 40 years (Gout ≤ 40) and > 40 years, and normouricemic healthy controls (HC). Plasma samples were collected from 94 asymptomatic HUA (77% HUA ≤ 40) subjects, 196 gout patients (59% Gout ≤ 40), and 53 HC. A comprehensive targeted lipidomic analysis was performed to semi-quantify 608 lipids in plasma. Univariate and multivariate statistics and advanced visualizations were applied. Both HUA and gout patients showed alterations in lipid profiles with the most significant upregulation of phosphatidylethanolamines and downregulation of lysophosphatidylcholine plasmalogens/plasmanyls. More profound changes were observed in HUA ≤ 40 and Gout ≤ 40 without ULT. Multivariate statistics differentiated HUA ≤ 40 and Gout ≤ 40 groups from HC with an overall accuracy of > 95%. Alterations in the lipidome of HUA and Gout patients show a significant impact on lipid metabolism. The most significant glycerophospholipid dysregulation was found in HUA ≤ 40 and Gout ≤ 40 patients, together with a correction of this imbalance with ULT.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30226 - Rheumatology

Result continuities

  • Project

    <a href="/en/project/NU22-01-00465" target="_blank" >NU22-01-00465: Characteristics and consequences of genetic variants associated with hyperuricemia, gout progression, disease onset, and treatment effects: a perspective on an early diagnosis and individualized treatment in clinical practice</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Arthritis Research and Therapy.

  • ISSN

    1478-6354

  • e-ISSN

    1478-6362

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    Art.Nr. 234

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    16

  • Pages from-to

    1-16

  • UT code for WoS article

    001112934800001

  • EID of the result in the Scopus database

    2-s2.0-85178341393