Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F23%3AN0000009" target="_blank" >RIV/00023728:_____/23:N0000009 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10472364 RIV/00216208:11320/23:10472364 RIV/00098892:_____/23:10158303 RIV/00064165:_____/23:10472364
Result on the web
<a href="https://doi.org/10.1186/s13075-023-03204-6" target="_blank" >https://doi.org/10.1186/s13075-023-03204-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13075-023-03204-6" target="_blank" >10.1186/s13075-023-03204-6</a>
Alternative languages
Result language
angličtina
Original language name
Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
Original language description
Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be affected by urate-lowering treatment (ULT). Our study aimed to evaluate differences in plasma lipidome between patients with asymptomatic HUA detected ≤ 40 years (HUA ≤ 40) and > 40 years, gout patients with disease onset ≤ 40 years (Gout ≤ 40) and > 40 years, and normouricemic healthy controls (HC). Plasma samples were collected from 94 asymptomatic HUA (77% HUA ≤ 40) subjects, 196 gout patients (59% Gout ≤ 40), and 53 HC. A comprehensive targeted lipidomic analysis was performed to semi-quantify 608 lipids in plasma. Univariate and multivariate statistics and advanced visualizations were applied. Both HUA and gout patients showed alterations in lipid profiles with the most significant upregulation of phosphatidylethanolamines and downregulation of lysophosphatidylcholine plasmalogens/plasmanyls. More profound changes were observed in HUA ≤ 40 and Gout ≤ 40 without ULT. Multivariate statistics differentiated HUA ≤ 40 and Gout ≤ 40 groups from HC with an overall accuracy of > 95%. Alterations in the lipidome of HUA and Gout patients show a significant impact on lipid metabolism. The most significant glycerophospholipid dysregulation was found in HUA ≤ 40 and Gout ≤ 40 patients, together with a correction of this imbalance with ULT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
<a href="/en/project/NU22-01-00465" target="_blank" >NU22-01-00465: Characteristics and consequences of genetic variants associated with hyperuricemia, gout progression, disease onset, and treatment effects: a perspective on an early diagnosis and individualized treatment in clinical practice</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Arthritis Research and Therapy.
ISSN
1478-6354
e-ISSN
1478-6362
Volume of the periodical
25
Issue of the periodical within the volume
Art.Nr. 234
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
1-16
UT code for WoS article
001112934800001
EID of the result in the Scopus database
2-s2.0-85178341393