Characterization of LK-1 monoclonal antibody against human sialophorin (CD43).

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F00%3A00000063" target="_blank" >RIV/00023736:_____/00:00000063 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Characterization of LK-1 monoclonal antibody against human sialophorin (CD43).
Original language description
The CD43 molecule (sialophorin, leukosialin, sialoglycoprotein) is a heavily O-glycosylated and sialylated glycoprotein, consisting of 381 amino acid residues (Hořejší and Stockinger, 1997). CD43 is a type I transmembrane protein of 95 000-115 000 Mrwithan extracellular domain of 239 residues carrying an N-glycan chain and about 70-85 O-linked oligosaccharides (Pallant et al., 1989). A soluble form of CD43, called galactoglycoprotein, was detected in human blood plasma (Schmid et al., 1992). CD43 iexpressed on all human leukocytes except for the majority of resting B lymphocytes. Different cell types express CD43 forms differing in the degree of sialylation of the O-linked oligosaccharide chain. CD43 expression is tightly regulated on cells ofhematopoietic origin either by increasing or decreasing surface expression, or by post-translational modification, which results in precisely controlled glycosylated isoforms.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NI5884" target="_blank" >NI5884: Immunoregulatory function of cytokine and chemokine receptors in pathogenesis and pathophysiology of blood diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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