Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F03%3A00000001" target="_blank" >RIV/00023736:_____/03:00000001 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer.
Original language description
Aberrant splicing of huMDR1 is a complication for its potential use in gene therapy. We therefore prepared several variants of huMDR1 cDNA by site-directed mutagenesis to eliminate aberrant splicing in target cells. Based on functional tests a variant with better properties than wild type cDNA was found.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gene Therapy
ISSN
0969-7128
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
1061-1065
UT code for WoS article
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EID of the result in the Scopus database
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