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The effects of gene deletions in recombinant vaccinia virus (rVV) genome on anticancer immunity induced by rVV based vaccine.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F04%3AG0000036" target="_blank" >RIV/00023736:_____/04:G0000036 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effects of gene deletions in recombinant vaccinia virus (rVV) genome on anticancer immunity induced by rVV based vaccine.

  • Original language description

    Recombinant vaccina viruses (rVV) with either B8R, A44L, C7L or C23L/B29R genes deleted, expressing modified HPV16 E7 protein were tested as model vaccines against HPV16 to elicit the role of these genes for immunogenicity of rVV. Our results showed thatproduct of B8R gene did not affect cell-mediated immunity but increased tumor growth protection.

  • Czech name

    Vliv genových delecí v genomu rekombinantního viru vakcínie (rVV) na protinádorovou imunitu indukovanou rVV vakcínou.

  • Czech description

    Rekombinantní viry vakcínie (rVV) s deletovanými geny B8R, A44L, C7L nebo C23L/B29R exprimující modifikovaný protein E7 viru HPV16 jsme použili jako modelové vakcíny proti HPV16, abychom zjistili vliv těchto genů na imunogenitu rVV. Zjistili jsme, že produkt genu B8R neovlivňuje buněčnou imunitu, ale zlepšuje ochranu před nádory in vivo.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA310%2F04%2F0004" target="_blank" >GA310/04/0004: Factors of virulence of vaccinia virus and their role in induction of cell mediated immunity</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Microbiology and Infection

  • ISSN

    1198-743X

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    S3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    1

  • Pages from-to

    333

  • UT code for WoS article

  • EID of the result in the Scopus database