MicroRNA-451 in chronic myeloid leukemia: miR-451?BCR-ABL regulatory loop?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F11%3A00009163" target="_blank" >RIV/00023736:_____/11:00009163 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.leukres.2011.03.029" target="_blank" >http://dx.doi.org/10.1016/j.leukres.2011.03.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.leukres.2011.03.029" target="_blank" >10.1016/j.leukres.2011.03.029</a>

Result language
angličtina
Original language name
MicroRNA-451 in chronic myeloid leukemia: miR-451?BCR-ABL regulatory loop?
Original language description
Chronic myeloid leukemia (CML) is caused by constituve activity of BCR-ABL tyrosine kinase. Despite of high efficiency of imatinib, selective BCR-ABL inhibitor, about 30% of patients develop resistance. Novel markers and targets for therapy are thus necessary. MicroRNAs are small intereference RNAs whose role in physiological and malignant hematopoiesis has been shown. This study is focused on miR-451 in CML. Following our observation of miR-451 downregulation in CML, we further show its relation to BCR-ABL activity. Our data together with current literature indicate a more complex relationship of miR-451 and BCR-ABL in CML.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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