Evolution of human cytomegalovirus-seronegative donor/-seropositive recipient high-risk combination frequency in allogeneic hematopoietic stem cell transplantations at Institute of Hematology and Blood Transfusion during 1995-2014

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F16%3A00011527" target="_blank" >RIV/00023736:_____/16:00011527 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/tid.12508" target="_blank" >http://dx.doi.org/10.1111/tid.12508</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tid.12508" target="_blank" >10.1111/tid.12508</a>

Result language

angličtina

Original language name

Evolution of human cytomegalovirus-seronegative donor/-seropositive recipient high-risk combination frequency in allogeneic hematopoietic stem cell transplantations at Institute of Hematology and Blood Transfusion during 1995-2014

Original language description

Analyses of the HCMV serostatus of hematopoietic stem cell donors during 2 consecutive calendar periods (1995-2005 and 2006-2014) showed a significant increase in the proportion of seronegative donors (odds ratio [OR] = 1.947). In addition, the number of HSCT treatments using an unrelated donor increased (OR = 2.376). Finally, the use of grafts from countries with a very low HCMV prevalence increased. This increase in HCMV seronegativity in unrelated donors and the increased proportion of unrelated donors were responsible for the increased occurrence of the high-risk combination R+/D- (OR = 1.680). If the reduction in the rate of HCMV-seropositive graft donors continues, an increased frequency of HCMV reactivation events in our transplant recipients can be expected, because of the increasing occurrence of the high-risk R+/D- combination.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT13898" target="_blank" >NT13898: CMV specific mRNA vaccine for ex vivo stimulation of T cells in patiens after hematopoietic stem cell transplantation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplant infectious disease

ISSN

1398-2273

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

2

Country of publishing house

DK - DENMARK

Number of pages

5

Pages from-to

297-301

UT code for WoS article

000374379100022

EID of the result in the Scopus database

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