NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00012979" target="_blank" >RIV/00023736:_____/21:00012979 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/21:10436689
Result on the web
<a href="https://doi.org/10.1101/2020.02.06.936666" target="_blank" >https://doi.org/10.1101/2020.02.06.936666</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1101/2020.02.06.936666" target="_blank" >10.1101/2020.02.06.936666</a>

Result language
angličtina
Original language name
NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization
Original language description
Oligomerization of the nucleolar phosphoprotein nucleophosmin (NPM) is mediated by its N-terminal 50 domain. We introduce a reliable set of complementary methods for monitoring NPM 55 oligomerization in both cell lysates and live cells. Using this methodological background we show that 56 a putative inhibitor of NPM oligomerization, NSC348884, does not prevent formation of NPM 57 oligomers in leukemia cells. Instead, we reveal that the observed cytotoxic effect of NSC348884 is 58 associated with changes in cell adhesion signaling.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)