Correlation of p53 oligomeric status and its subcellular localization in the presence of the AML-associated NPM mutant
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F25%3A00013793" target="_blank" >RIV/00023736:_____/25:00013793 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/25:10498712 RIV/00216208:11310/25:10498712
Result on the web
<a href="https://doi.org/10.1371/journal.pone.0322096" target="_blank" >https://doi.org/10.1371/journal.pone.0322096</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0322096" target="_blank" >10.1371/journal.pone.0322096</a>
Alternative languages
Result language
angličtina
Original language name
Correlation of p53 oligomeric status and its subcellular localization in the presence of the AML-associated NPM mutant
Original language description
Tumor suppressor p53 is a key player in the cell response to DNA damage that suffers by frequent inactivating aberrations. Some of them disturb p53 oligomerization and influence cell decision between proliferation, growth arrest and apoptosis. Active p53 resides mostly in the nucleus, degradation occurs in the cytoplasm. Acute myeloid leukemia (AML)-related mutation of NPM (NPMmut) induces massive mislocalization of p53 to the cytoplasm, which might be related to leukemia initiation. Since both proteins interact and execute their function as oligomers, we investigated the role of perturbed p53 oligomerization in the p53 mislocalization process in live cells by FLIM (fluorescence lifetime imaging microscopy), fluorescence anisotropy imaging (FAIM), fluorescence cross-correlation spectroscopy (FCCS) and immunochemical methods.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS one
ISSN
1932-6203
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
26
Pages from-to
"art.no. e0322096"
UT code for WoS article
001488722300037
EID of the result in the Scopus database
2-s2.0-105004781315