Nucleolar phosphoprotein modifications as a marker of apoptosis induced by RITA treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F23%3A00013544" target="_blank" >RIV/00023736:_____/23:00013544 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.bbamcr.2023.119501" target="_blank" >https://doi.org/10.1016/j.bbamcr.2023.119501</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbamcr.2023.119501" target="_blank" >10.1016/j.bbamcr.2023.119501</a>
Alternative languages
Result language
angličtina
Original language name
Nucleolar phosphoprotein modifications as a marker of apoptosis induced by RITA treatment
Original language description
Reactivating p53 and Inducing Tumor Apoptosis (RITA) has been reported to increase the p53 activity and to trigger p53-dependent apoptosis in cancer cells with wild-type p53. Tumor suppressor p53 interacts with nucleolar phosphoproteins nucleophosmin (NPM) and nucleolin (NCL), which have crucial role in many cellular processes. Specific NPM mutations associated with acute myeloid leukemia (AML) cause aberrant localization of NPM and p53 in the cytoplasm with possible impact on the p53 function. We tested an effect of RITA on primary cells, and we found significant RITA-induced changes in NPM and NCL phosphorylation associated with apoptosis in cells of AML patients, but not that of healthy donors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/GA22-03875S" target="_blank" >GA22-03875S: Role of acute myeloid leukemia-associated nucleophosmin mutations in the NPM-p53-Mdm2 regulatory network</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica et biophysica acta: molecular cell research
ISSN
0167-4889
e-ISSN
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Volume of the periodical
1870
Issue of the periodical within the volume
7
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
"art. no. 119501"
UT code for WoS article
001054977000001
EID of the result in the Scopus database
2-s2.0-85161284731