AML-associated mutation of nucleophosmin compromises its interaction with nucleolin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F18%3A00012024" target="_blank" >RIV/00023736:_____/18:00012024 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.biocel.2018.08.008" target="_blank" >https://doi.org/10.1016/j.biocel.2018.08.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biocel.2018.08.008" target="_blank" >10.1016/j.biocel.2018.08.008</a>
Alternative languages
Result language
angličtina
Original language name
AML-associated mutation of nucleophosmin compromises its interaction with nucleolin
Original language description
C-terminal mutations of the nucleolar protein nucleophosmin (NPM) are the most frequent genetic aberration detected in acute myeloid leukemia (AML) with normal karyotype. We analyzed the impact of the mutation on NPM interaction with nucleolin (NCL) which is also prevalently localized into the nucleolus and cooperates with wild-type NPM (NPMwt) in many cellular processes. We revealed that the NCL-NPM complex formation is completely abolished by the mutation and that the presence/absence of the interaction is not affected by drugs causing genotoxic stress or differentiation. Deregulation resulting from changes of NCL/NPMwt ratio may contribute to leukemogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV16-30268A" target="_blank" >NV16-30268A: Mutated nucleophosmin as a potential target for immunotherapy of acute myelogenous leukemia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of biochemistry and cell biology
ISSN
1357-2725
e-ISSN
—
Volume of the periodical
103
Issue of the periodical within the volume
[October]
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
65-73
UT code for WoS article
000447100000007
EID of the result in the Scopus database
2-s2.0-85051919047