ABCB1 amplicon contains cyclic AMP response element-driven TRIP6 gene in taxane-resistant MCF-7 breast cancer sublines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F23%3A00013518" target="_blank" >RIV/00023736:_____/23:00013518 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/23:00014188 RIV/00216208:11120/23:43925160 RIV/00216208:11310/23:10457078 RIV/00216208:11140/23:10457078
Result on the web
<a href="https://doi.org/10.3390/genes14020296" target="_blank" >https://doi.org/10.3390/genes14020296</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/genes14020296" target="_blank" >10.3390/genes14020296</a>
Alternative languages
Result language
angličtina
Original language name
ABCB1 amplicon contains cyclic AMP response element-driven TRIP6 gene in taxane-resistant MCF-7 breast cancer sublines
Original language description
A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant MCF-7 sublines (manifesting even higher TRIP6 expression). We found that TRIP6 transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines, TRIP6 co-amplification with the neighboring ABCB1 gene, as witnessed by fluorescence in situ hybridization (FISH), led to TRIP6 overexpression. Ultimately, we found high TRIP6 mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genes
ISSN
2073-4425
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
23
Pages from-to
"art. no. 296"
UT code for WoS article
000944841000001
EID of the result in the Scopus database
2-s2.0-85148869540