Activation of TLRs by opportunistic fungi in lung organoids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F23%3A00013558" target="_blank" >RIV/00023736:_____/23:00013558 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-1-0716-3366-3_16" target="_blank" >http://dx.doi.org/10.1007/978-1-0716-3366-3_16</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-0716-3366-3_16" target="_blank" >10.1007/978-1-0716-3366-3_16</a>

Result language
angličtina
Original language name
Activation of TLRs by opportunistic fungi in lung organoids
Original language description
Organoid cultures may express several types of pattern-recognition receptors and in particular toll-like receptors, representing an extremely efficient and innovative system to understand how pathogen-associated molecular patterns exposure may affect the immunity, the growth, or differentiation of complex tissues. Here, we describe how to generate lung organoids from human-induced pluripotent stem cells. Three-dimensional (3D) cultures are then stimulated with different toll-like receptor ligands derived from fungi or with Aspergillus fumigatus. RNA sequencing may be performed upon organoid cultures to understand host–pathogen innate immune interactions.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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