Functional glutamate receptors are expressed in rat brain capillary barrier

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F03%3A00000322" target="_blank" >RIV/00023752:_____/03:00000322 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Functional glutamate receptors are expressed in rat brain capillary barrier

Original language description

Glutamate, a major excitatory neurotransmitter, exerts a direct effect on cerebral capillary barrier, a structure that is characterized by high-resistance endothelial tight junctions, minimal endothelial pinocytosis and investment of the brain surface ofthe endothelium by astrocytic processes. We demonstrated that rat brain capillaries possess functional glutamate receptors of NMDA-type (and also AMPA-type and mGluR 1). Therefore, quinolinic acid (QUIN; an endogenous agonist of NMDA receptors), that isformed in retrovirus-infected perivascular microphages and microglia from tryptophan, may influence permeability of the rat brain capillary barrier by lipid peroxidation (determined as total lipid fluorescent products). Substances, exhibiting both an antagonist action on the NMDA receptors and antioxidant properties, can prevent the QUIN-induced lipid peroxidation in isolated rat brain microvessels. Involvement of glutamate receptors in the BBB dysfunction (presumed in some neuropsychia

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NF7626" target="_blank" >NF7626: Levels of brain glutamate and subunit composition of glutamate receptor of NMDA type in schiziphrenia: experimantal and clinical study.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

2

Pages from-to

127-128

UT code for WoS article

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EID of the result in the Scopus database

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