Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020060" target="_blank" >RIV/67985823:_____/02:20020060 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/02:00000206

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.

Original language description

The findings indicate that both the NMDA subtype of iGluR and group I of mGluR are susceptible to the QUIN-induced neurodegeneration in the rat hippocampus. The inhibition of NO synthesis does not reveal any protective action in the QUIN-evoked, NMDA-receptor mediated decrease of [(H]Glu membrane binding. Thus, the additional mechanisms of QUIN action, different from direct NMDA receptor activa-tion/NO production (e.g. lipid peroxidation induced by QUIN-Fe-complexex) cannot be excluded.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GA309%2F99%2F0211" target="_blank" >GA309/99/0211: Localization, distribution and function of glutamate receptor in brain capillary barrier</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

51

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

299-307

UT code for WoS article

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EID of the result in the Scopus database

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