Sad mood induction has an opposite effect on amygdala response to emotional stimuli in euthymic patients with bipolar disorder and healthy controls

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F15%3A43914664" target="_blank" >RIV/00023752:_____/15:43914664 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/15:43909237 RIV/00023001:_____/15:00059362

Result on the web

<a href="http://jpn.ca/vol40-issue2/40-2-134/" target="_blank" >http://jpn.ca/vol40-issue2/40-2-134/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1503/jpn.140044" target="_blank" >10.1503/jpn.140044</a>

Result language

angličtina

Original language name

Sad mood induction has an opposite effect on amygdala response to emotional stimuli in euthymic patients with bipolar disorder and healthy controls

Original language description

Aberrant amygdala reactivity to affective stimuli represents a candidate factor predisposing patients with bipolar disorder (BD) to relapse, but it is unclear to what extent amygdala reactivity is state-dependent. We evaluated the modulatory influence of mood on amygdala reactivity and functional connectivity in patients with remitted BD and healthy controls. Amygdala response to sad versus neutral faces was investigated using fMRI during periods of normal and sad mood induced by autobiographical scripts. We assessed the functional connectivity of the amygdala to characterize the influence of mood state on the network responsible for the amygdala response. We included 20 patients with remitted BD and 20 controls in our study. The sad and normal mood exerted opposite effects on the amygdala response to emotional faces in patients compared with controls (F1,38 = 5.85, p = 0.020). Sad mood amplified the amygdala response to sad facial stimuli in controls but attenuated the amygdala response in patients. The groups differed in functional connectivity between the amygdala and the inferior prefrontal gyrus (p LESS-THAN OR EQUAL TO 0.05, family-wise error-corrected) of ventrolateral prefrontal cortex (vlPFC) corresponding to Brodmann area 47. The sad mood challenge increased connectivity during the period of processing sad faces in patients but decreased connectivity in controls. Limitations to our study included long-term medication use in the patient group and the fact that we mapped only depressive (not manic) reactivity. Our results support the role of the amygdala-vlPFC as the system of dysfunctional contextual affective processing in patients with BD. Opposite amygdala reactivity unmasked by the mood challenge paradigm could represent a trait marker of altered mood regulation in patients with BD.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

—

Project

<a href="/en/project/NT12024" target="_blank" >NT12024: Electrophysiological correlates of emotional neurocircuits in depression, bipolar affective disorder and healthy population.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Psychiatry &amp; Neuroscience

ISSN

1180-4882

e-ISSN

—

Volume of the periodical

40

Issue of the periodical within the volume

2

Country of publishing house

CA - CANADA

Number of pages

9

Pages from-to

134-142

UT code for WoS article

000351206800009

EID of the result in the Scopus database

2-s2.0-84923483460