Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00103532" target="_blank" >RIV/00216224:14110/18:00103532 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.pscychresns.2018.08.012" target="_blank" >http://dx.doi.org/10.1016/j.pscychresns.2018.08.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pscychresns.2018.08.012" target="_blank" >10.1016/j.pscychresns.2018.08.012</a>

Result language

angličtina

Original language name

Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder

Original language description

Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PSYCHIATRY RESEARCH-NEUROIMAGING

ISSN

0925-4927

e-ISSN

1872-7506

Volume of the periodical

280

Issue of the periodical within the volume

OCT 30 2018

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

56-61

UT code for WoS article

000443824900008

EID of the result in the Scopus database

2-s2.0-85052334399