PARTICLE - The RNA podium for genomic silencers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919852" target="_blank" >RIV/00023752:_____/19:43919852 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43918223
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28739" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28739</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jcp.28739" target="_blank" >10.1002/jcp.28739</a>
Alternative languages
Result language
angličtina
Original language name
PARTICLE - The RNA podium for genomic silencers
Original language description
Radiation exposure can evoke cellular stress responses. Emerging recognition that long non‐coding RNAs (lncRNAs) act as regulators of gene expression has broadened the spectra of molecules controlling the genomic landscape upon alterations in environmental conditions. Knowledge of the mechanisms responding to low dose irradiation (LDR) exposure is very limited yet most likely involve subtle ancillary molecular pathways other than those protecting the cell from direct cellular damage. The discovery that transcription of the lncRNA PARTICLE (promoter of MAT2A‐ antisense radiation‐induced circulating lncRNA; PARTICL) becomes dramatically instigated within a day after LDR exposure introduced a new gene regulator onto the biological landscape. PARTICLE affords an RNA binding platform for genomic silencers such as DNA methyltransferase 1 and histone tri‐methyltransferases to reign in the expression of tumor suppressors such as its neighboring MAT2A in cis as well as WWOX in trans. In silico evidence offers scope to speculate that PARTICLE exploits the abundance of Hoogsten bonds that exist throughout mammalian genomes for triplex formation, presumably a vital feature within this RNA silencer. PARTICLE may provide a buffering riboswitch platform for S‐adenosylmethionine. The correlation of PARTICLE triplex formation sites within tumor suppressor genes and their abundance throughout the genome at cancer‐related hotspots offers an insight into potential avenues worth exploring in future therapeutic endeavors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular Physiology
ISSN
0021-9541
e-ISSN
—
Volume of the periodical
234
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
19464-19470
UT code for WoS article
000478018200030
EID of the result in the Scopus database
2-s2.0-85065430770