Ultralong TE In Vivo H-1 MR Spectroscopy of Omega-3 Fatty Acids in Subcutaneous Adipose Tissue at 7 T
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43920313" target="_blank" >RIV/00023752:_____/19:43920313 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/19:00078051
Result on the web
<a href="https://www.researchgate.net/publication/329869555_Ultralong_TE_In_Vivo_1_H_MR_Spectroscopy_of_Omega-3_Fatty_Acids_in_Subcutaneous_Adipose_Tissue_at_7_T_Omega-3_Fatty_Acids_Detection_at_7_T" target="_blank" >https://www.researchgate.net/publication/329869555_Ultralong_TE_In_Vivo_1_H_MR_Spectroscopy_of_Omega-3_Fatty_Acids_in_Subcutaneous_Adipose_Tissue_at_7_T_Omega-3_Fatty_Acids_Detection_at_7_T</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jmri.26605" target="_blank" >10.1002/jmri.26605</a>
Alternative languages
Result language
angličtina
Original language name
Ultralong TE In Vivo H-1 MR Spectroscopy of Omega-3 Fatty Acids in Subcutaneous Adipose Tissue at 7 T
Original language description
Background Omega‐3 (n‐3) fatty acids (FA) play and important role in neural development and other metabolic diseases such as obesity and diabetes. The knowledge about the in vivo content and distribution of n‐3 FA in human body tissues is not well established and the standard quantification of FA is invasive and costly. Purpose To detect omega‐3 (n‐3 CH3) and non‐omega‐3 (CH3) methyl group resonance lines with echo times up to 1200 msec, in oils, for the assessment of n‐3 FA content, and the n‐3 FA fraction in adipose tissue in vivo. Study Type Prospective technical development. Population Three oils with different n‐3 FA content and 24 healthy subjects. Field Strength/Sequence Single‐voxel MR spectroscopy (SVS) with a point‐resolved spectroscopy (PRESS) sequence with an echo time (TE) of 1000 msec at 7 T. Assessment Knowledge about the J‐coupling evolution of both CH3 resonances was used for the optimal detection of the n‐3 CH3 resonance line at a TE of 1000 msec. The accuracy of the method in oils and in vivo was validated from a biopsy sample with gas chromatography analysis. Statistical Tests SVS data were compared to gas chromatography with the Pearson correlation coefficient. Results T2 relaxation times in oils were assessed as follows: CH2, 65 ± 22 msec; CH3, 325 ± 7 msec; and n‐3 CH3, 628 ± 34 msec. The n‐3 FA fractions from oil phantom experiments (n = 3) were in agreement with chromatography analysis and the comparison of in vivo obtained data with the results of chromatography analysis (n = 5) yielded a significant correlation (P = 0.029). Data Conclusion PRESS with ultralong‐TE can detect and quantify the n‐3 CH3 signal in vivo at 7 T. Level of Evidence 1 Technical Efficacy Stage 1
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Magnetic Resonance Imaging
ISSN
1053-1807
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
71-82
UT code for WoS article
000471831600006
EID of the result in the Scopus database
2-s2.0-85058969321