The day‐night differences in ERK1/2, GSK3β activity and c‐Fos levels in the brain, and the responsiveness of various brain structures to morphine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F20%3A43920370" target="_blank" >RIV/00023752:_____/20:43920370 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/cne.24906" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/cne.24906</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cne.24906" target="_blank" >10.1002/cne.24906</a>

Result language

angličtina

Original language name

The day‐night differences in ERK1/2, GSK3β activity and c‐Fos levels in the brain, and the responsiveness of various brain structures to morphine

Original language description

As with other drugs or pharmaceuticals, opioids differ in their rewarding or analgesic effects depending on when they are applied. In the previous study, we have demonstrated the day/night difference in the sensitivity of the major circadian clock in the suprachiasmatic nucleus to a low dose of morphine, and showed the bidirectional effect of morphine on pERK1/2 and pGSK3 beta levels in the suprachiasmatic nucleus depending on the time of administration. The main aim of this study was to identify other brain structures that respond differently to morphine depending on the time of its administration. Using immunohistochemistry, we identified 44 structures that show time-of-day specific changes in c-Fos level and activity of ERK1/2 and GSK3 beta kinases in response to a single dose of 1 mg/kg morphine. Furthermore, comparison among control groups revealed the differences in the spontaneous levels of all markers with a generally higher level during the night, that is, in the active phase of the day. We thus provide further evidence for diurnal variations in the activity of brain regions outside the suprachiasmatic nucleus indicated by the temporal changes in the molecular substrate. We suggest that these changes are responsible for generating diurnal variation in the reward behavior or analgesic effect of opioid administration.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Comparative Neurology

ISSN

0021-9967

e-ISSN

—

Volume of the periodical

528

Issue of the periodical within the volume

14

Country of publishing house

US - UNITED STATES

Number of pages

25

Pages from-to

2471-2495

UT code for WoS article

000522073500001

EID of the result in the Scopus database

2-s2.0-85082423129