The day-night differences in ERK1/2, GSK3 beta activity and c-Fos levels in the brain, and the responsiveness of various brain structures to morphine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10422955" target="_blank" >RIV/00216208:11310/20:10422955 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QzcOsN_jBU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QzcOsN_jBU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cne.24906" target="_blank" >10.1002/cne.24906</a>
Alternative languages
Result language
angličtina
Original language name
The day-night differences in ERK1/2, GSK3 beta activity and c-Fos levels in the brain, and the responsiveness of various brain structures to morphine
Original language description
As with other drugs or pharmaceuticals, opioids differ in their rewarding or analgesic effects depending on when they are applied. In the previous study, we have demonstrated the day/night difference in the sensitivity of the major circadian clock in the suprachiasmatic nucleus to a low dose of morphine, and showed the bidirectional effect of morphine on pERK1/2 and pGSK3 beta levels in the suprachiasmatic nucleus depending on the time of administration. The main aim of this study was to identify other brain structures that respond differently to morphine depending on the time of its administration. Using immunohistochemistry, we identified 44 structures that show time-of-day specific changes in c-Fos level and activity of ERK1/2 and GSK3 beta kinases in response to a single dose of 1 mg/kg morphine. Furthermore, comparison among control groups revealed the differences in the spontaneous levels of all markers with a generally higher level during the night, that is, in the active phase of the day. We thus provide further evidence for diurnal variations in the activity of brain regions outside the suprachiasmatic nucleus indicated by the temporal changes in the molecular substrate. We suggest that these changes are responsible for generating diurnal variation in the reward behavior or analgesic effect of opioid administration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GA16-13399S" target="_blank" >GA16-13399S: Maternal separation in a model of early life stress-induced psychosis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Comparative Neurology
ISSN
0021-9967
e-ISSN
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Volume of the periodical
528
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
25
Pages from-to
2471-2495
UT code for WoS article
000522073500001
EID of the result in the Scopus database
2-s2.0-85082423129