Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation Stat

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920675" target="_blank" >RIV/00023752:_____/21:43920675 - isvavai.cz</a>
Result on the web
<a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad201409" target="_blank" >https://content.iospress.com/articles/journal-of-alzheimers-disease/jad201409</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-201409" target="_blank" >10.3233/JAD-201409</a>

Result language
angličtina
Original language name
Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation Stat
Original language description
Neuroblastoma cell line SH-SY5Y, due to its capacity to differentiate into neurons, easy handling, and low cost, is a common experimental model to study molecular events leading to Alzheimer's disease (AD). However, it is prevalently used in its undifferentiated state, which does not resemble neurons affected by the disease. Here, we show that the expression and localization of amyloid-β protein precursor (AβPP), one of the key molecules involved in AD pathogenesis, is dramatically altered in SH-SY5Y cells fully differentiated by combined treatment with retinoic acid and BDNF. We show that insufficient differentiation of SH-SY5Y cells results in AβPP mislocalization.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30210 - Clinical neurology

Project
<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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