Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation State
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00544239" target="_blank" >RIV/61388955:_____/21:00544239 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921594 RIV/00216208:11310/21:10428066
Result on the web
<a href="http://hdl.handle.net/11104/0321269" target="_blank" >http://hdl.handle.net/11104/0321269</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-201409" target="_blank" >10.3233/JAD-201409</a>
Alternative languages
Result language
angličtina
Original language name
Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation State
Original language description
Neuroblastoma cell line SH-SY5Y, due to its capacity to differentiate into neurons, easy handling, and low cost, is a common experimental model to study molecular events leading to Alzheimer's disease (AD). However, it is prevalently used in its undifferentiated state, which does not resemble neurons affected by the disease. Here, we show that the expression and localization of amyloid-β protein precursor (AβPP), one of the key molecules involved in AD pathogenesis, is dramatically altered in SH-SY5Y cells fully differentiated by combined treatment with retinoic acid and BDNF. We show that insufficient differentiation of SH-SY5Y cells results in AβPP mislocalization.n
Czech name
—
Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GJ19-08304Y" target="_blank" >GJ19-08304Y: Role of mTORC1 signalling in intracellular processing and trafficking of Alzheimer’s disease-associated amyloid precursor protein and its derivatives</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Alzheimer's Disease
ISSN
1387-2877
e-ISSN
1875-8908
Volume of the periodical
82
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
485-491
UT code for WoS article
000677582000003
EID of the result in the Scopus database
2-s2.0-85111397319