Attention impairment in motor functional neurological disorders: a neuropsychological study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F22%3A43920906" target="_blank" >RIV/00023752:_____/22:43920906 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/22:10449344 RIV/00216208:11110/22:10449344 RIV/00216208:11210/22:10449344 RIV/00216208:11230/22:10449344

Result on the web

<a href="https://link.springer.com/article/10.1007/s00415-022-11211-x" target="_blank" >https://link.springer.com/article/10.1007/s00415-022-11211-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-022-11211-x" target="_blank" >10.1007/s00415-022-11211-x</a>

Result language

angličtina

Original language name

Attention impairment in motor functional neurological disorders: a neuropsychological study

Original language description

Objective Our objective was to assess cognitive functioning across multiple cognitive domains using a standardised neuropsychological battery in patients with motor functional neurological disorders (mFND). Methods Thirty patients with clinically established mFND and 30 age-, sex- and education-matched control subjects underwent a thorough neuropsychological assessment evaluating (1) attention including processing speed, (2) executive functions including working memory, (3) short-term memory, (4) speech and language and (5) visuospatial functions. Performance validity tests (PVT) and self-report measures of depression, anxiety and cognitive complaints were included in the assessment. Only patients with valid test performance were included in the analysis. Results Three patients scored below the cut-off scores in PVT. Patients performed significantly worse than controls in the following areas: (1) the attention domain which included a slow processing speed (p = 0.005, Cohen&apos;s d = 0.89), (2) executive functions (p = 0.01, Cohen&apos;s d = 0.88) and (3) speech and language domains (p = 0.025, Cohen&apos;s d = 0.77). Patients with mFND showed greater intra-individual variability in cognitive performance (p = 0.005, Cohen&apos;s d = 0.94). Cognitive impairments were independent of depressive symptoms, which were higher in mFND patients. Conclusion This study revealed both subjective and objective cognitive impairment in patients with mFND. The neuropsychological profile in mFND was characterised primarily by attentional impairment including a slow processing speed and a high intra-individual variability in cognitive performance. Cognitive impairment was associated with a valid test performance, highlighting that the deficits observed were not likely to be explained by a lack of effort in the patient group. Attention is considered to play a key role in mFND pathophysiology, and the results suggest that such impairments are objectively measurable.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/NV16-29651A" target="_blank" >NV16-29651A: Diagnostic neurophysiological and laboratory markers and pathophysiological mechanisms of functional movement disorders</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurology

ISSN

0340-5354

e-ISSN

1432-1459

Volume of the periodical

269

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

5981-5990

UT code for WoS article

000826269600001

EID of the result in the Scopus database

2-s2.0-85134478587