The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43920991" target="_blank" >RIV/00023752:_____/23:43920991 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/23:43924450
Result on the web
<a href="https://linkinghub.elsevier.com/retrieve/pii/S0304394022005389" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S0304394022005389</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2022.136977" target="_blank" >10.1016/j.neulet.2022.136977</a>
Alternative languages
Result language
angličtina
Original language name
The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia
Original language description
Background: Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) diminishes auditory hallu-cinations (AHs). The aims of our study were a) to assess the efficacy of LF-rTMS in a randomized, sham-controlleddouble-blind alignment, b) to identify the electrophysiological changes accompanying the LF-rTMS, and c) toidentify the influence of LF-rTMS on brain functional connectivity (FC).Methods: Nineteen schizophrenia patients with antipsychotic-resistant AHs were randomized to either active (n= 10) or sham (n = 9) LF-rTMS administered over the left temporo-parietal region for ten days. The clinical effectwas assessed by the Auditory Hallucination Rating Scale (AHRS). The localization of the differences in electricalactivity was identified by standardized low resolution brain electromagnetic tomography (sLORETA) and FC wasmeasured by lagged phase synchronization.Results: AHRS scores were significantly improved for patients receiving active rTMS compared to the sham(median reduction: 40 % vs 12 %; p = 0.01). sLORETA revealed a decrease of alpha-2, beta-1,-2 bands in the lefthemisphere in the active group. Active rTMS led to a decrease of the lagged phase connectivity in beta bandsoriginating in areas close to the site of stimulation, and to a prevailing increase of alpha-2 FC. No significantdifferences in current density or FC were observed in the sham group.Limitations: Limitations to our study included the small group sizes, and the disability of LORETA to assesssubcortical neuronal activity.Conclusions: LF-rTMS attenuated AHs and induced a decrease of higher frequency bands on the left hemisphere. The FC changes support the assumption that LF-rTMS is linked to the modulation of cortico-cortical coupling.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience Letters
ISSN
0304-3940
e-ISSN
1872-7972
Volume of the periodical
794
Issue of the periodical within the volume
"Article number 136977"
Country of publishing house
IE - IRELAND
Number of pages
7
Pages from-to
1-7
UT code for WoS article
000904998700005
EID of the result in the Scopus database
2-s2.0-85143736457