Cognitive impairment associated with Hodgkin's lymphoma and chemotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921034" target="_blank" >RIV/00023752:_____/23:43921034 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10454860 RIV/00216208:11120/23:43925093 RIV/00064173:_____/23:43925093
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0304394023000368?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0304394023000368?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2023.137082" target="_blank" >10.1016/j.neulet.2023.137082</a>
Alternative languages
Result language
angličtina
Original language name
Cognitive impairment associated with Hodgkin's lymphoma and chemotherapy
Original language description
Chemotherapy-related cognitive impairment (CRCI) is a well-documented side effect of cancer treatment in various types of tumors including Hodgkin’s lymphoma (HL). However, a longitudinal study evaluating the cognitive performance of HL patients has been completely lacking.The aim of the study was to determine the presence of CRCI in HL patients before, promptly after, and 6 months after treatment. Thirty-six patients newly diagnosed with HL and 45 healthy controls (HC) completed the neuropsychological battery and psychological measures of affective distress and quality of life.The results indicate that HL patients have impaired performance compared to HC which cannot be explained by emotional factors. Cognitive impairments prior to treatment were found in 3 of 6 cognitive domains, i.e., verbal memory and learning, speed of processing/psychomotor speed, and abstraction/executive function. Promptly after the chemotherapy, deficits were found in the domains of memory and learning, verbal memory, speed of processing/psychomotor speed, and abstraction/executive function. Weaker cognitive performance persist even 6 months after the end of chemotherapy, specifically in domains of verbal memory and learning, and abstraction/executive function. Our results indicate the presence of cognitive impairment in HL patients already prior to treatment and increased damages caused by chemotherapy, while some of them may last for up to 6 months after the treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
50103 - Cognitive sciences
Result continuities
Project
<a href="/en/project/NV16-29857A" target="_blank" >NV16-29857A: Cognitive impairment, structural and functional brain morphological sequelae of Hodgkin lymphoma treatment: Translational study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience Letters
ISSN
0304-3940
e-ISSN
1872-7972
Volume of the periodical
797
Issue of the periodical within the volume
"Article Number: 137082"
Country of publishing house
IE - IRELAND
Number of pages
6
Pages from-to
1-6
UT code for WoS article
000926489000001
EID of the result in the Scopus database
2-s2.0-85147015813