Inflammation and cognitive performance in first-episode schizophrenia spectrum disorders: The moderating effects of childhood trauma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921156" target="_blank" >RIV/00023752:_____/23:43921156 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11210/23:10469330 RIV/00216208:11110/23:10469330 RIV/00216208:11120/23:43926069
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0920996423003456" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0920996423003456</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.schres.2023.09.034" target="_blank" >10.1016/j.schres.2023.09.034</a>
Alternative languages
Result language
angličtina
Original language name
Inflammation and cognitive performance in first-episode schizophrenia spectrum disorders: The moderating effects of childhood trauma
Original language description
In this study, we aimed to determine whether childhood trauma moderated the relationship between inflammation and cognitive functioning in persons with first-episode schizophrenia spectrum disorders (SSDs). We included data from 92 individuals who participated in the nationwide Early-Stage Schizophrenia Outcome study. These individuals completed the Childhood Trauma Questionnaire, provided a fasting blood sample for high-sensitivity C-reactive protein analysis, and underwent extensive neuropsychological testing. The intervening effects of age, sex, education, smoking status, and body mass index were controlled. Results indicated that childhood trauma levels significantly moderated the relationship between inflammation and four cognitive domains: speed of processing, working memory, visual memory, and verbal memory. Inflammation also predicted verbal memory scores irrespective of childhood trauma levels or the covariates. Upon further exploration, the significant moderation effects appeared to be primarily driven by males. In conclusion, a history of childhood trauma may be an important determinant in evaluating how inflammation relates to the cognitive performance of people with first-episode SSDs, particularly in speed of processing, working memory, visual memory, and verbal memory. We recommend that future researchers examining the effect of inflammation on cognitive functioning in SSDs include trauma as a moderating variable in their models and further examine additional moderating effects of sex.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
50103 - Cognitive sciences
Result continuities
Project
<a href="/en/project/NU22-D-135" target="_blank" >NU22-D-135: Cognitive functioning after a COVID-19 diagnosis in individuals with schizophrenia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Schizophrenia Research
ISSN
0920-9964
e-ISSN
1573-2509
Volume of the periodical
261
Issue of the periodical within the volume
November
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
185-193
UT code for WoS article
001149577800001
EID of the result in the Scopus database
2-s2.0-85172271083