Investigation of anti-neuronal antibodies and disparity in central hypersomnias

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921208" target="_blank" >RIV/00023752:_____/24:43921208 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/24:00579545 RIV/00216208:11110/24:10472293 RIV/00216208:11120/24:43926229 RIV/00064165:_____/24:10472293

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1389945723004653?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1389945723004653?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sleep.2023.11.039" target="_blank" >10.1016/j.sleep.2023.11.039</a>

Result language

angličtina

Original language name

Investigation of anti-neuronal antibodies and disparity in central hypersomnias

Original language description

Study objectives: Microbial antigens can elicit an immune response leading to the production of autoantibodies cross-reacting with autoantigens. Still, their clinical significance in human sera in the context of brain diseases is unclear. Therefore, assessment of natural autoantibodies reacting with their neuropeptides may elucidate the autoimmune etiology of central hypersomnias. The study aims to determine whether serum autoantibody levels differ in patients with different types of central hypersomnias (narcolepsy type 1 and 2, NT1 and NT2; idiopathic hypersomnia, IH) and healthy controls and if the differences could suggest the participation of autoantibodies in disease pathogenesis.Methods: Sera from 91 patients with NT1, 27 with NT2, 46 with IH, and 50 healthy controls were examined for autoantibodies against assorted neuropeptides. Participants were screened using questionnaires related to sleep disorders, quality of life, and mental health conditions. In addition, serum biochemical parameters and biomarkers of microbial penetration through the intestinal wall were determined.Results: A higher prevalence of autoantibodies against neuropeptides was observed only for alpha-melanocytesstimulating hormone (alpha-MSH) and neuropeptide glutamic acid-isoleucine (NEI), which differed slightly among diagnoses. Patients with both types of narcolepsy exhibited signs of microbial translocation through the gut barrier. According to the questionnaires, patients diagnosed with NT2 or IH had subjectively worse life quality than patients with NT1. Patients displayed significantly lower levels of bilirubin and creatinine and slightly higher alkaline phosphatase values than healthy controls.Conclusions: Overall, serum anti-neuronal antibodies prevalence is rare, suggesting that their participation in the pathophysiology of concerned sleep disorders is insignificant. Moreover, their levels vary slightly between diagnoses indicating no major diagnostic significance.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/NU20-04-00088" target="_blank" >NU20-04-00088: Gut microbiome and autoimmune mechanisms in patients with central hypersomnia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sleep Medicine

ISSN

1389-9457

e-ISSN

1878-5506

Volume of the periodical

113

Issue of the periodical within the volume

January

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

220-231

UT code for WoS article

001139104100001

EID of the result in the Scopus database

2-s2.0-85179033816