Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10495450" target="_blank" >RIV/00064165:_____/25:10495450 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10495450
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Uu-W-kuNnI" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Uu-W-kuNnI</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.sleep.2025.02.019" target="_blank" >10.1016/j.sleep.2025.02.019</a>
Alternative languages
Result language
angličtina
Original language name
Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia
Original language description
Objective and background: Health-related quality of life (HRQoL) is reduced in narcolepsy type 1 (NT1), but proper information on HRQoL in narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) is lacking. This study examines HRQoL of NT1, NT2, IH, and healthy controls (HC) and assesses the HRQoL associates in these diseases. Patients and methods: 117 adults (64 NT1, 22 NT2, 31 IH; 61.5 % women; 38.3 +- 12.0 years; 71.8 % treated) and 41 HC (53.7 % women; 35.9 +- 9.6 years) completed questionnaires assessing sleepiness, fatigue, symptoms severity, sleep inertia, depressive and anxiety symptoms, HRQoL, and underwent a semi-structured interview. Data were analyzed using the Mann-Whitney and Kruskal-Wallis tests, Spearman's correlation coefficient, and regression analysis. Results: HRQoL of NT1, NT2, and IH, separately, was poorer compared to HC (p < 0.001). According to the 36-Item Short Form Health Survey, the mental HRQoL was more impaired in NT2 and IH than NT1 (p < 0.05) in association with more pronounced depressive symptoms (p < 0.01; p < 0.05, respectively) and sleep inertia (p < 0.01; p < 0.01, respectively). Psychiatric disorders were more prevalent in NT2 and IH versus NT1 (p < 0.05). Conclusion: HRQoL is reduced in NT1, NT2, and IH, with this reduction being more pronounced in NT2 and IH. Poor mental HRQoL of NT2 and IH was associated both with the severity of depressive symptoms and more intense sleep inertia.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30300 - Health sciences
Result continuities
Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sleep Medicine
ISSN
1389-9457
e-ISSN
1878-5506
Volume of the periodical
129
Issue of the periodical within the volume
May
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
31-39
UT code for WoS article
001430017700001
EID of the result in the Scopus database
2-s2.0-85217893476