Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10337401" target="_blank" >RIV/00064165:_____/16:10337401 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10337401 RIV/00023736:_____/16:00011723
Result on the web
<a href="http://dx.doi.org/10.1007/s00005-016-0435-5" target="_blank" >http://dx.doi.org/10.1007/s00005-016-0435-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00005-016-0435-5" target="_blank" >10.1007/s00005-016-0435-5</a>
Alternative languages
Result language
angličtina
Original language name
Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias
Original language description
The aim of our study was to analyze the distribution of HLA-DQB1 in Czech patients with central hypersomnias and differences between diagnostic groups of narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) and no central hypersomnia subjects (no-CH). Statistical analysis of DQB1 genotyping was performed on the cohort of 716 patients (375 men, 341 women) with reported excessive daytime sleepiness. DQB1*06:02 allele was present in 94% of the NT1 patients. The decrease of DQB1*06:03 allele was also confirmed. No other DQB1*06 allele nor any other DQB1 allele group was differently distributed in the NT1. In the cohort of NT2 patients DQB1*06:02 allele was present in 43%. Allele group DQB*05 was detected with a significantly higher frequency in this diagnostic unit. Any differences in presence of DQB1*05 alleles in NT2 patients were not reported so far. The cohort of patients with IH did not show any difference in allele distribution of DQB1 alleles/allele groups comparing to healthy controls. DQB1*06:02 allele was significantly increased in the no hypersomnia group. No other DQB1 allele/allele group had any difference in distribution in patients comparing to healthy controls. The different distribution of DQB1*06:02 and other DQB1 alleles/allele groups was detected in analyzed diagnostic groups. These results indicate that DQB1 contributes to the genetic predisposition to NT1, NT2, IH and no-CH in different manners.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archivum Immunologiae et Therapiae Experimentalis
ISSN
0004-069X
e-ISSN
—
Volume of the periodical
64
Issue of the periodical within the volume
Suppl. 1
Country of publishing house
PL - POLAND
Number of pages
10
Pages from-to
89-98
UT code for WoS article
—
EID of the result in the Scopus database
2-s2.0-85009278991