Effects of botulinum toxin on pain control mechanisms, muscle structure and cortical reorganization, a mini-review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921525" target="_blank" >RIV/00023752:_____/25:43921525 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928359
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0041010125001175?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0041010125001175?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.toxicon.2025.108343" target="_blank" >10.1016/j.toxicon.2025.108343</a>

Result language
angličtina
Original language name
Effects of botulinum toxin on pain control mechanisms, muscle structure and cortical reorganization, a mini-review
Original language description
Spasticity often results in significant disability, which complicates rehabilitation and daily activities. This review explores the role of botulinum toxin type A (BoNT-A) in the treatment of spasticity, focusing on its effects on muscle structure and activity, function, cortical reorganization, and pain. Our findings indicate that BoNT-A injections improve motor function and gait, particularly in stroke patients, by reducing abnormal muscle activity and enhancing postural control. However, BoNT-A may also induce unwanted biomechanical changes, such as muscle atrophy and alterations in contractile elements, which could impact long-term muscle function.Regarding pain management in spasticity, BoNT-A has shown promise by reducing both peripheral and central sensitization mechanisms. Additionally, BoNT-A influences the central nervous system (CNS) by inducing cortical reorganization, which may further contribute to clinical improvements.Lastly, BoNT-A treatment requires careful consideration of individual patient characteristics to optimize outcomes and minimize side effects. A multidisciplinary approach that combines BoNT-A with physical therapy is essential to maximize functional recovery and improve the quality of life in patients with spasticity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/EH22_008%2F0004643" target="_blank" >EH22_008/0004643: Brain dynamics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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