The Central Effects of Botulinum Toxin in Dystonia and Spasticity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73607315" target="_blank" >RIV/61989592:15110/21:73607315 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/21:N0000032
Result on the web
<a href="https://www.mdpi.com/2072-6651/13/2/155" target="_blank" >https://www.mdpi.com/2072-6651/13/2/155</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/toxins13020155" target="_blank" >10.3390/toxins13020155</a>
Alternative languages
Result language
angličtina
Original language name
The Central Effects of Botulinum Toxin in Dystonia and Spasticity
Original language description
In dystonic and spastic movement disorders, however different in their pathophysiological mechanisms, a similar impairment of sensorimotor control with special emphasis on afferentation is assumed. Peripheral intervention on afferent inputs evokes plastic changes within the central sensorimotor system. Intramuscular application of botulinum toxin type A (BoNT-A) is a standard evidence-based treatment for both conditions. Apart from its peripheral action on muscle spindles, a growing body of evidence suggests that BoNT-A effects could also be mediated by changes at the central level including cerebral cortex. We review recent studies employing electrophysiology and neuroimaging to investigate how intramuscular application of BoNT-A influences cortical reorganization. Based on such data, BoNT-A becomes gradually accepted as a promising tool to correct the maladaptive plastic changes within the sensorimotor cortex. In summary, electrophysiology and especially neuroimaging studies with BoNT-A further our understanding of pathophysiology underlying dystonic and spastic movement disorders and may consequently help develop novel treatment strategies based on neural plasticity
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxins
ISSN
2072-6651
e-ISSN
—
Volume of the periodical
13
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
"'155(1)'"-"'155(21)'"
UT code for WoS article
000623305700001
EID of the result in the Scopus database
2-s2.0-85102607879