How Much Evidence do we have on the Central Effects of Botulinum Toxin in Spasticity and Dystonia?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160717" target="_blank" >RIV/61989592:15110/16:33160717 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5772/64763" target="_blank" >http://dx.doi.org/10.5772/64763</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/64763" target="_blank" >10.5772/64763</a>
Alternative languages
Result language
angličtina
Original language name
How Much Evidence do we have on the Central Effects of Botulinum Toxin in Spasticity and Dystonia?
Original language description
Abstract The brain is continually reorganizing (plasticity). Plastic changes within the sensorimotor system are not only beneficial (adaptive plasticity) but may even worsen function (maladaptive plasticity). Conditions such as dystonia and poststroke spasticity (PSS) that interfere with motor performance could be attributed to maladaptive plasticity. Botulinum toxin (BoNT) has been proven to be safe and effective in treating various hyperfunctional cholinergic states. Beside the well-known neuromuscular junction site of action, BoNT also exerts effects through supraspinal mechanisms and can even affect cortical reorganization. The hypothesis of central reorganization following BoNT treatment has been supported by studies using neurophysiological and imaging methods in patients with focal dystonia and PSS. The growing evidence of BoNT-related central (remote) effects make BoNT injections a promising tool to favorably affect maladaptive changes even at the cortical level.
Czech name
—
Czech description
—
Classification
Type
C - Chapter in a specialist book
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/NV15-31921A" target="_blank" >NV15-31921A: Prevalence of spasticity in patients suffering from ischaemic stroke in the internal carotid artery territory</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Botulinum Toxin Therapy Manual for Dystonia and Spasticity
ISBN
978-953-51-2852-6
Number of pages of the result
9
Pages from-to
—
Number of pages of the book
180
Publisher name
IN TECH d.o.o.
Place of publication
Rijeka
UT code for WoS chapter
—