Changes of BMI, steroid metabolome and psychopathology in patients with anorexia nervosa during hospitalization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F20%3AN0000004" target="_blank" >RIV/00023761:_____/20:N0000004 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10399754 RIV/00216208:11120/20:43918907 RIV/00064165:_____/20:10399754
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0039128X19302132?token=4F96B81483853A407C2B0F5AAB9E4733CDBD499A412353D28A43742D182AF4704C33ED6476BFE8FFC73CB83C29902D40" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0039128X19302132?token=4F96B81483853A407C2B0F5AAB9E4733CDBD499A412353D28A43742D182AF4704C33ED6476BFE8FFC73CB83C29902D40</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Changes of BMI, steroid metabolome and psychopathology in patients with anorexia nervosa during hospitalization
Original language description
Anorexia nervosa (AN) is associated with various alterations including the dysfunction of the HPA axis and consequently the hypercortisolemia and deficit in sex hormones but the comprehensive evaluation of changes in circulating steroids during the hospitalization of AN patients is lacking. We investigated the effect of realimentation of women with AN during hospitalization on 45 circulating steroids, the relationships between BMI, its change during hospitalization and physical activity, on one side and initial levels and their changes for two adipokines, circulating steroids, anorexia-specific (hunger, appetite and satiety), and anorexia non-specific symptoms (anxiety, depression fatigue, sleep, and body pain) on the other side. We included 33 women with anorexia who were hospitalized for 38 (35, 44) days (median with quartiles). The increase of BMI from the initial value 15.2 (13.2, 16.6) kg/m(2) was 1.69 (1.37, 2.66) kg/m(2). The patients with more severe anorexia showed higher activity in 7 beta-, and 16 alpha-hydroxylation of androgen precursors, which declined during hospitalization. Otherwise, the 7 alpha-hydroxylation activity is higher in AN patients with less severe malnutrition and the ratio of 5-androstene-3 beta,7 alpha,17 beta-triol to 5-androstene-3j3,7]3,17|3-triol increased during the realimentation. Our data allow to speculate that the intensive 7 beta-, and 16 alpha- and possibly also the 7 alpha-hydroxylation of C19 Delta(5) steroids participate in the pathophysiology of anorexia by additional catabolism of substrates available for synthesis of active androgens and estrogens. However, the question remains whether the synthetic analogues of 7 alpha/beta- and 16 alpha-hydroxy-steroids prevent the catabolism of the sex steroid precursors, or further activate the "energy wasting" mitochondrial thermogenic metabolism.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
1878-5867
Volume of the periodical
153
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
nestrankovano
UT code for WoS article
000509615100010
EID of the result in the Scopus database
2-s2.0-85074053048