Androst-5-ene-3β,7α/β,17β-triols, their plasma levels and dependence on the hypothalamic–pituitary–adrenal axis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F18%3AN0000022" target="_blank" >RIV/00023761:_____/18:N0000022 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Androst-5-ene-3β,7α/β,17β-triols, their plasma levels and dependence on the hypothalamic–pituitary–adrenal axis
Original language description
Androst-5-ene-triols are metabolites of dehydroepiandrosterone, the most abundant steroid hormone in human circulation. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7 beta-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3 beta,7 beta,17 beta-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on the levels and effects of androst-5-ene-triols in experimental animals and of their the pharmacological perspective, little is known about androst-5-ene-3 beta,7 alpha/beta,17 beta-triols circulating in human blood, their regulation by the hypothalamo-pituitary-adrenal axis, or their daily concentration variability. Here we provide some data on androst-5-ene-3 beta,7 alpha/beta,17 beta-triol concentrations under various conditions in men and women.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
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Volume of the periodical
134
Issue of the periodical within the volume
June
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
88-95
UT code for WoS article
000432503000010
EID of the result in the Scopus database
2-s2.0-85044087249