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Adaptation of Cryptosporidium oocysts to different excystation conditions

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F07%3A%230000417" target="_blank" >RIV/00027014:_____/07:#0000417 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Adaptation of Cryptosporidium oocysts to different excystation conditions

  • Original language description

    Within the bacteria genus Cryptosporidium, two lineages (adapted to gastric or small intestine environments) have evolved. We tested whether the excystation (releasing of sporozoites), is triggered by conditions mimicking the site of infection (acid or neutral conditions). We found that oocysts from the gastric species C. muris and, C. andersoni excysted in both conditions, whereas the intestinal species C. parvum and C. hominis did not respond to acid. Testing the effect of temperature on C. muris andC. parvum alone, only C. parvum oocysts were excysted significantly. Oocysts from intestinal species did not respond to or temperature alone, nor to acidity. These observations indicate that Cryptosporidium oocysts have evolved to maximize delivery of sporozoites to the region of the gastro-intestinal tract where the parasite multiplies.

  • Czech name

    Adaptace oocyst rodu Cryptosporidium na různé podmínky excystace

  • Czech description

    U bakterií rodu Cryptosporidium se vyvinuly 2 linie (přizpůsobené prostředí žaludku a slezu, nebo prostředí tenkého střeva). Zjišťovali jsme, zda excystaci (uvolnění sporozoitů) spouštějí podmínky imitující místo infekce (nízké nebo neutrální pH). U oocyst žaludečních druhů C. muris a C. andersoni probíhala excystace vždy, zatímco střevní druhy C. parvum a C. hominis nereagovaly v kyselém prostředí. Vlivem samotné teploty na C. muris a C. parvum došlo k signifikantní excystaci jen u C. parvum. Oocysty střevních druhů nereagovaly ani na samotnou teplotu, ani na kyselost. Tato zjištění naznačují, že se u oocyst Cryptosporidií vyvinula schopnost maximálního rozšíření sporozoitů do té oblasti gastrointestinálního traktu, kde se parazit množí.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    GJ - Diseases and animal vermin, veterinary medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Parasitology

  • ISSN

    0031-1820

  • e-ISSN

  • Volume of the periodical

    134

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    1583-1588

  • UT code for WoS article

  • EID of the result in the Scopus database