Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F09%3A%230001104" target="_blank" >RIV/00027014:_____/09:#0001104 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocytes
Original language description
In fully grown pig oocytes, meiotic maturation in vitro is slowed by inhibition of histone deacetylases by trichostatin A (TSA). In growing oocytes with partial meiotic competence, the culture with TSA has no significant effect on the meitic maturation.Growing oocytes treated with TSA mature mainly to the stage of metaphase I. The ratio of oocytes maturing to the stage of metaphase II is very limited. After the transient exposure to TSA, the maturation of growing oocytes with partial meiotic competencetakes another course. When these oocytes are first cultured in TSA-free medium, then cultured for another 24 hours with 100 nM TSA and finally they are again cultured in TSA-free medium for 24 hours, the ratio of oocytes maturing to the stage of metaphase II is significantly increased and it reached 59%. When oocytes are cultured for the same time without transient exposure to TSA, only 19% matured to the stage of metaphase II.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/QG50052" target="_blank" >QG50052: Reproductive biotechniques in pigs</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Zygote
ISSN
0967-1994
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
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UT code for WoS article
000271184000004
EID of the result in the Scopus database
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