Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F09%3A31165" target="_blank" >RIV/60460709:41210/09:31165 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte

Original language description

In fully-grown pig oocytes, meiotic maturation in vitro is retarded by inhibition ofhistone deacetylases by trichostatin A (TSA). In growing oocytes with partial meiotic competence, culture with TSA has no significant effect on the meitic maturation. Growing oocytes treated with TSA mature mainly to the stage of metaphase I. The ratio of oocytes maturing tothe stage of metaphase II is very limited. After transient exposure to TSA, the maturation of growing oocytes with partial meiotic competence takes adifferent course. When these oocytes are first cultured in a TSA-free medium, then cultured for another 24 hours with 100 nM TSA, and finally again inaTSA-free medium for 24 hours, the ratio of oocytes maturing to the stage of metaphase II significantlyincreases reaching 59%. When oocytes were cultured for the same length of time without transient exposure to TSA, only 19% matured to the stage of metaphase II. Those oocytes which matured to the stage of metaphase II after transient exp

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GG - Zootechnics

OECD FORD branch

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Project

<a href="/en/project/QG50052" target="_blank" >QG50052: Reproductive biotechniques in pigs</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Zygote

ISSN

0967-1994

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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