Acute low-dose bisphenol S exposure affects mouse oocyte quality

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F20%3AN0000052" target="_blank" >RIV/00027014:_____/20:N0000052 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/20:84530 RIV/00216208:11110/20:10403489 RIV/00216208:11140/20:10403489
Result on the web
<a href="https://vuzv.cz/_privat/20050.pdf" target="_blank" >https://vuzv.cz/_privat/20050.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.reprotox.2019.12.005" target="_blank" >10.1016/j.reprotox.2019.12.005</a>

Result language
angličtina
Original language name
Acute low-dose bisphenol S exposure affects mouse oocyte quality
Original language description
Bisphenol S (BPS) is widely used to replace the known endocrine disruptor BPA in various products. We evaluated the effect of acute in vivo BPS exposure on oocyte quality, simulating the oral route of exposure via oral gavage. Eight-week-old ICR female mice (N = 15 per experimental group) were exposed to vehicle or BPS1-BPS4 (0.001, 0.1, 10, and 100 ng BPS x g bw(-1) day(-1), respectively) for seven days. Oocytes were isolated and matured in vitro. We observed that BPS exposure increased aberrant spindle formation in mature oocytes and induced DNA damage. Moreover, BPS3 significantly increased the chromatin repressive marks 5-methyl cytosine (5meC) and H3K27me2 in immature oocytes. In the BPS2 group, the increase in 5meC occurred during oocyte maturation. Transcriptome analysis revealed differential expression of early embryonic development transcripts in BPS2-exposed oocytes. These findings indicate that the biological effect of BPS is non-monotonic, affecting oocyte quality even at concentrations that are orders of magnitude below those measured in humans.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)